淋巴结生发中心进行性转化一例报告--附文献复习

Progressive transformation of lymph node germinal centers： a case report and literature review

目的 提高对淋巴结生发中心进行性转化（PTGC）的认识,探讨其临床特征、组织病理学和免疫组织化学特点及其与生发中心增生的相关疾病的鉴别诊断并对相关文献进行复习.方法 报告1例淋巴结生发中心进行性转化患者的临床特征和实验室检查指标及诊治经过.结果 患者主要表现为无痛性外周淋巴结肿大,病理组织学表现为滤泡增生,出现进行性转化的生发中心,生发中心和套区淋巴细胞边界不清.免疫组织化学检查示转化的生发中心细胞CD20＋、CD5＋、CDw75＋.结论 PTGC是一种临床少见的淋巴结病,组织病理学和免疫组织化学辅助检查是其诊断的重要依据.

Objective To improve the understanding of progressive transformation of lymph node germinal centers （PTGC） and to explore its clinical, histopathologic and immunohistoohemical features and the differential diagnosis between the related disease of germinal center hyperplasia.Methods The clinical manifestation, laboratory bindings, treatment and outcome of a patient with PTGC were presented.Results The main manifestation of the patient was painless peripheral lymphadenopathy.Histopathologic examination of an axillary lymph node showed reactive follicular hyperplasia and the progressive transformation changes germinal centers.The borderline between the germinal center and the mantle layer was obscured.The cells in the progressive transforming germinal centers were positive for CD20~＋、CD5~＋、CDw75~＋.Conclusion FFGC is a rare lymphoid disorder.Histopathology and immunohistochemistry are important basis of the diagnosis.