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阵发性睡眠性血红蛋白尿症及再生障碍性贫血患者WT1基因启动子区甲基化状态的研究 被引量：2

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摘要 阵发性睡眠性血红蛋白尿症（PNH）患者常有反复的血红蛋白尿和持久的贫血,究竟是什么原因导致PNH克隆优势造血呢？研究表明,WT1基因启动子区DNA甲基化状态是使PNH克隆大量扩增的机制之一.我们采用甲基化特异性PCR（MSP）法研究PNH患者、再生障碍性贫血（AA）患者WTI基因启动子区域DNA甲基化模式的改变,初步探讨表观遗传学调控方式在PNH和AA发病机制中的作用.
作者 王树叶 杨喜晶 曹峰林 周晋
机构地区 哈尔滨医科大学附属第一医院血液内科 上海市普陀区人民医院血液科
出处 《中华血液学杂志》 CAS CSCD 北大核心 2010年第4期273-274,共2页 Chinese Journal of Hematology
关键词 阵发性睡眠性血红蛋白尿症 再生障碍性贫血患者 基因启动子区域 甲基化状态 WT1 甲基化特异性 甲基化模式 表观遗传学
分类号 R55 [医药卫生—血液循环系统疾病]
  • 相关文献

参考文献3

  • 1Shichishima T,Okamoto M,Ikeda K,et al.HLA class II haplo-type and quantitation of WT1 RNA in Japanese patients with paroxysmal nocturnal hemoglobinuria.Blood,2002,100;22-28.
  • 2赵晔,陈子兴,胡绍燕,岑建农,顾伟英.造血系统肿瘤WT1基因启动子区域DNA甲基化及其调控的研究[J].中华血液学杂志,2005,26(9):517-520. 被引量：3
  • 3Loeb DM,Evron E,Patel CB,et al.Wilms' tumor suppressor gene(WT1) is expressed in primary breast tumors despite tumor-specific promoter methylation.Cancer Res,2001,61:921-925.

二级参考文献16

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共引文献2

同被引文献28

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中华血液学杂志
2010年 第4期

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