摘要
目的:回顾性分析三维适形放射治疗胰腺癌的预后因子及PET/CTSUV值与胰腺癌疗效相关性。方法:26位胰腺癌患者三维适形放疗前2周内行18FDGPET/CT扫描并计算SUV值。放疗剂量2.5～3.0Gy/次,6次/周,总剂量≥50.0Gy。患者完成三维适形放射治疗后3个月评价早期疗效分为完全缓解(CR)、部分缓解(PR)、病变稳定(SD)和疾病进展(PD),对相关指标进行单因素和多因素分析。结果:三维适形放射治疗后达到CR和PR的胰腺癌患者,其SUV值明显低于放疗达SD和PD的患者,差异有统计学意义,P<0.05。提示分化程度高、增殖能力差的胰腺癌患者三维适形放射治疗疗效好。在预后的多因素分析中,SUV值是胰腺癌患者放疗有效(CR+PR)的独立预后因素,SUV值的OR值为2.943。结论PET扫描及计算SUV值能够预测胰腺癌三维适形放射治疗的疗效。
OBJECTIVE：To retrospective analyze the prognosis of patients and the dependability of 18Fluorodeoxyglucose standardized uptake value and the therapeutic efficacy with pancreatic cancer treated with 3-dimension conformal radiation therapy （3DCRT）. METHODS：Twenty-six pancreatic cancer patients underwent PET/CT within 2 weeks before 3-dimensional conformal radiation therapy,and SUV was calculated. Radiotherapy was delivered at 2.5-3.0 Gy per fraction,6 fractions per week with a total dose of more than 50.0 Gy. The therapeutic efficacy of 3-dimensional conformal radiation therapy was evaluated 3 months after finishing therapy,according to pantients＇ response which was classified as complete response,partial response,stable disease and progressive disease. The impact of related prognostic factors on survival was evaluated by univariate and multivariate analyses. RESULTS：The SUV of patients who got complete response or partial response was obviously lower than those who got stable disease or progressive disease,the difference was significance（P〈0.05）. It indicated that pancreatic cancer patients who were high cell differentiation extent and bad generation capability can get good therapeutic effect after 3-dimensional conformal radiation therapy. In the multiplicity of predictive factor,SUV was the predictive factor for complete and partial response,and OR of SUV was 2.943. CONCLUSION：PET and SUV can be used as the important predictive factors for the therapeutic efficacy of 3-dimensional conformal radiation therapy in pancreatic cancer patients.
出处
《中华肿瘤防治杂志》
CAS
2010年第1期65-69,共5页
Chinese Journal of Cancer Prevention and Treatment
