丝裂霉素C与羟基喜树碱预防膀胱癌复发的Meta分析

A Meta-analysis on the prevention of recurrence of bladder cancer with mitomycin C and hydroxycamptothecin

目的比较丝裂霉素C(MMC)与羟基喜树碱(HCPT)膀胱灌注对膀胱癌复发的预防作用及治疗毒性。方法筛选13个临床研究,包括416例进行MMC、595例进行HCPT膀胱灌注治疗的患者,进行系统分析。采用优势比(OR)及95%可信区间(95%CI)作为评价疗效及毒性差异的指标。统计软件为RevMan5。结果Meta分析显示,HCPT膀胱灌注治疗预防肿瘤复发的疗效显著优于MMC(P<0.01)。MMC组膀胱刺激症状、外周血白细胞数下降的发生率显著高于HCPT组(分别为P<0.01)。结论HCPT膀胱灌注预防膀胱癌复发作用优于MMC,且治疗毒性低于MMC。

Objective To compare the efficacy and toxicity of intravesical irrigation of mitomycin C（MMC） versus hydroxycamptothecin（HCPT） in preventing the recurrence of bladder cancer.Methods A total of 13 trials was eligible for the inclusion criteria,of which 416 patients were treated with MMC and 595 cases with HCPT.Odds ratio（OR） and its 95% confidence interval（CI） were used as the comparison parameter of efficacy and toxicity.The statistical analysis was performed using RevMan5 software.Results The results of Meta-analysis showed that HCPT was significantly superior to MMC in the prevention of tumor recurrence with less irritation sign of bladder and peripheral blood leucocyte descendent（P0.01）.Conclusion The results of this meta-analysis suggest that intravesical irrigation of HCPT is better than that of MMC in preventing the recurrence of bladder cancer.