尿钠排泄量与动脉弹性指数的关系

Relationship between Urinary Sodium Excretion and Arterial Compliance

目的探讨尿钠排泄量与大小动脉弹性指数(C1,C2)的关系。方法入选体检人群397例(男性195例,女性202例),年龄(53.4±15.1)岁。通过24 h尿钠排泄量测定钠盐摄入量,将入选人群分为低盐组(n=99),低中盐组(n=100),中高盐组(n=99),高盐组(n=99)。C1、C2采用CVProfilor Do-2020动脉脉搏波分析仪测量。使用广义线性模型比较24 h尿钠排泄量与C1、C2的关系,使用多元线性回归分析影响C1、C2的主要因素。结果随着24 h尿钠排泄量的增多,C1、C2逐步降低,其中高盐组较低盐组C1、C2显著降低。多元逐步线性回归分析结果提示24 h尿钠排泄量增高是C1、C2降低的独立危险因素。结论随着24 h尿钠排泄量的增加,反映动脉弹性的指标C1、C2下降。

Objective To investigate the relationship between urinary sodium excretion and large arterial compliance（C1） and small arterial compliance（C2）.Methods We enrolled 397 subjects [mean age（53.4±15.1）years,including 195 men and 202 women].These subjects were divided into 4 groups according to their 24-hour urinary sodium excretion,which reflected dietary sodium intake.C1 and C2 were measured by pulse wave analysis（CVProfilor Do-2020）.Statistical methods included general linear model and stepwise regression analysis.Results With increased 24-hour urinary sodium excretion,C1 and C2 decreased.Compared with low sodium intake group,high sodium intake group had a significant lower C1 and C2.Stepwise regression analysis revealed that 24-hour urinary sodium excretion was independently associated with C1 and C2.Conclusion C1 and C2 decreased with increased 24-hour urinary sodium excretion.