山东东部地区女性喉癌患者的临床特点

Clinical features of laryngeal carcinoma in females in the East of Shandong Province

目的探讨山东东部地区女性喉癌患者的临床特点。方法对22例女性喉癌患者资料进行回顾性分析,其中声门上型8例,声门型13例,声门下型1例;按2002年AJCC标准进行分期:Ⅰ期10例,Ⅱ期2例,Ⅲ期4例,Ⅳ期6例。行喉部分切除术14例,喉全切除术6例,同时行颈清扫术10例,术后放疗10例。单纯放疗2例。生存率采用直接法计算。结果行手术治疗的20例中,治疗后满3年者11例,失访2例,无瘤生存8例,3年直接生存率72.7%;治疗后满5年者6例,失访1例,无瘤生存5例,5年直接生存率83.3%;行单纯放射治疗的2例分别于治疗后9个月和1年死于复发。结论女性喉癌发病率较低,声门上型喉癌构成比相对较高,部分女性喉癌患者与吸烟有关,女性喉癌患者的多原发癌值得重视。

Objective To investigate the clinical features of laryngeal carcinoma in females in the East of Shandong Province.Methods Twenty-two female patients with laryngeal carcinoma were retrospectively analyzed,including 8 cases of supraglottic carcinoma,13 cases of glottic carcinoma and 1 case of subglottic carcinoma.According to AJCC（2002）,there were 10 cases in stageⅠ,2 cases in stageⅡ,4 cases in stage Ⅲ,and 6 cases in stage Ⅳ.Partial laryngectomy was performed in 14 patients and total laryngectomy in 6 patients.10 patients underwent neck dissection synchronously.Radiotherapy was performed in 10 patients after surgery.And 2 patients only received radiotherapy.The direct method was used to calculate the survival rate.Results Among the 20 patients who received surgery,11 were followed up for more than 3 years：2 were missed and 8 had disease-free survival.The 3-year survival rate was 72.7%.Only 6 patients were followed up for more than 5 years：1 was missed and 5 had disease-free survival.The 5-year survival rate was 83.3%.The two patients who only received radiotherapy died because of relapse in 9 months and 1 year after treatment.Conclusion Laryngeal carcinoma in females has a low incidence.Supraglottic carcinoma is relatively common in female patients.Smoking is an important factor in some females.Multiple primary carcinomas should be focused on in females.