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SOCS3及Eotaxin-2在变应性鼻炎中的表达及意义 被引量：1

Expressions of SOCS3 and Eotaxin-2 in allergic rhinitis
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摘要 目的研究SOCS3及Eotaxin-2在变态反应性鼻炎(AR)鼻黏膜中的表达及其相互关系和临床意义。方法取20例AR患者(AR组)和15例单纯鼻中隔偏曲患者(对照组)鼻黏膜为研究对象,应用免疫组织化学技术分别检测SOCS3及Eotaxin-2的表达,并分析SOCS3及Eotaxin-2表达的相关性。结果在AR患者鼻黏膜中,SOCS3及Eotaxin-2的表达上调,在鼻黏膜炎性细胞、上皮细胞、腺体细胞、血管内皮细胞均呈显著性表达。SOCS3的平均光密度值为0.2401±0.01463,Eotaxin-2为0.2398±0.01423,与对照组相比,差异均有统计学意义(P均<0.01)。AR患者鼻黏膜中SOCS3及Eotaxin-2的表达具有相关性(r(0.951,P<0.01)。结论AR患者SOCS3及Eotaxin-2在鼻黏膜组织中表达增高,且二者呈正相关。 Objective To investigate expressions of SOCS3 and Eotaxin-2 in allergic rhinitis（AR）.Methods Twenty cases of allergic rhinitis nasal mucosa tissues served as the experimental group and fifteen cases of deflection of nasal septum nasal mucosa tissues as the control group.Immunohistochemisty was used to detect expressions of SOCS3 and Eotaxin-2.The relationship between SOCS3 and Eotaxin-2 expressions was analyzed.Results SOCS3 and Eotaxin-2 expressions were increased in AR patients.There was positive staining in inflammatory cells,vascular endothelial cells,epithelial cells and glandular epithelium cells.Compared with the control group,expressions of SOCS3（0.240 1±0.0146 3）and of Eotaxin-2（0.239 8±0.0142 3）were significantly higher than in the control group（P〈0.01）.SOCS3 expression was closely related to Eotaxin-2 expression（r=0.951,P〈0.01）.Conclusion Increased expressions of SOCS3 and Eotaxin-2 in allergic rhinitis are well evidenced.SOCS3 shows positive correlation with Eotaxin-2.
作者 王新龙 赵建东
机构地区 山东大学医学院 山东大学第二医院耳鼻咽喉科
出处 《山东大学耳鼻喉眼学报》 CAS 2010年第2期26-29,共4页 Journal of Otolaryngology and Ophthalmology of Shandong University
关键词 鼻炎 变应性 细胞因子信号转导抑制因子3 Eotaxin-2 Rhinitis allergic Suppressor of cytokine singnaling-3 Eotaxin-2
分类号 R765.21 [医药卫生—耳鼻咽喉科]
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参考文献9

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同被引文献16

  • 1张志明,孙树岩,王寿忱,季文樾,关超.Eotaxin基因在真菌诱导的变应性鼻炎鼻黏膜中的表达及其意义[J].临床耳鼻咽喉科杂志,2005,19(2):78-81. 被引量：4
  • 2周明辉,董明敏,吴玉瑛,王亮,岳保红.Eotaxin基因和趋化因子受体3在变应性鼻炎大鼠模型鼻腔黏膜和骨髓中的表达及意义[J].临床耳鼻咽喉科杂志,2006,20(5):227-230. 被引量：8
  • 3中华耳鼻咽喉头颈外科杂志编辑委员会 中华医学会耳鼻喉科分会.变应性鼻炎的诊治原则和推荐方案.中华耳鼻咽喉头颈外科杂志,2005,12(2):166-167.
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  • 8Zimmermann N, Daugherty BL, Stark JM, et al. Molecular a- nalysis of CCR-3 events in eosinophilic cells [ J ]. J Immunol, 2000,164(5) :1055 -1064.
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山东大学耳鼻喉眼学报
2010年 第2期

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