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重组人甲状旁腺激素（1-34）对骨质疏松患者血清Cbfa-1和MMP-13水平的影响 被引量：2

Effects of recombinant human PTH （1-34） on serum Cbfa-1 and MMP-13 levels in women with osteoporosis
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摘要 探讨重组人甲状旁腺素[rhPTH（1-34）]对绝经后骨质疏松患者血清核心结合因子a-1（Cbfa-1）和基质金属蛋白酶13（MMP-13）水平的影响。rhPTH（1-34）治疗6个月后，血清Cbfa-1[（54．0±2．4）对（62．2±2．8）μg／L，P〈0．05]、MMP-13[（2．51±0．15）对（3．96±0．24）μg／L，P〈0．01]显著降低；相关性分析显示治疗前血清Cbfa-1与MMP-13呈正相关（r=0．74，P〈0．01）。提示小剂量rhPTH（1-34）皮下注射能促进骨的合成，并使血清Cbfa-1和MMP-13水平下降。 The effect of recombinant human PTH （1-34） [ rhPTH （ 1-34 ） ] on serum core binding factor a-1 （ Cbfa-1 ） and matrix metalloproteinase-13 （ MMP-13 ） levels in women with osteoporosis was investigated. The results showed that Cbfa-1 [ （54.0 ± 2.4 ） vs （ 62.2 ± 2.8 ）μg/L, P〈 0.05 ] and MMP-13 [ （ 2.51± 0. 15 ） vs （3.96±0.24）μg/L, P〈0. 01 ] were significantly decreased after 6-month treatment. The basal serum Cbfa-1 level was positively correlated with that of MMP-13 （r=0.74, P〈0.01 ）. Small doses of PTH （1-34） were able to stimulate bone formation and lower the levels of serum Cbfa-1 and MMP-13.
作者 邓广江 李伶 杨刚毅 朱伟 李生兵
机构地区 重庆医科大学附属第二医院内分泌科 重庆医科大学检验系临床生化教研室和教育部实验诊断重点实验室
出处 《中华内分泌代谢杂志》 CAS CSCD 北大核心 2010年第4期309-310,共2页 Chinese Journal of Endocrinology and Metabolism
关键词 重组人甲状旁腺素(1-34) 核心结合因子a—1 基质金属蛋白酶13 骨质疏松症 Recombinant human parathyroid hormone （1-34） Core binding factor a-1 Matrix metalloproteinase-13 Osteoporosis
分类号 R580 [医药卫生—内分泌]
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参考文献8

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同被引文献20

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中华内分泌代谢杂志
2010年 第4期

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