IVF-ET过程中不同受精方式对治疗结局的影响

The Outcomes of Different Insemination Methods during IVF-ET

目的:探讨在辅助生殖过程中不同受精方式对妊娠结局的影响。方法:选择2005年1月—2008年8月在天津中心妇产科医院生殖助孕中心进行体外受精-胚胎移植(IVF-ET)的不孕症患者1470例,按受精方式分为2组,A组为常规体外受精患者1009例;B组为卵胞浆单精子注射(ICSI)患者461例。比较2组促性腺激素(Gn)用量、超促排卵(COH)天数、发育卵泡数、获卵数、临床妊娠情况以及畸形率等指标是否存在差异。结果:A组患者的Gn始量、Gn总量明显高于B组,COH天数明显长于B组;A组患者人绒毛膜促性腺激素(hCG)注射日雌激素(E2)水平、发育卵泡数、获卵数明显低于B组;2组患者临床妊娠数、单胎妊娠率、多胎妊娠率、流产率、异位妊娠率以及胎儿畸形率差异无统计学意义。结论:与常规IVF相比,ICSI是一种有效的治疗男性因素不孕的方法。

Objective：To investigate the outcomes of different insemination methods during in vitro fertilization-embryo transfer （IVF-ET）. Methods：One thousand four hundred and seventy patients,who attended the Tianjin Central Hospital of Obstetrics and Gynecology,from 2005 to 2008,were divided into 2 groups,1 009 patients in group A received conventional insemination; 461 patients in group B received intracytoplasmic sperm injection （ICSI）. The values of the gonadotrophins （Gn） dosage,days of controlled ovarian hyperstimulation （COH）,number of growing follicles,number of egg retrieval,clinical pregnancy rate,abortion rate and the malformation rate were compared between group A and group B. Results：The Gn dosage was higher and days of COH was longer in group A than those in group B. The estrogen level,the number of growing follicle and the number of egg retrieval were lower in group A than those in group B. There were no differences in the clinical pregnancy rate,abortion rate and malformation rate between the two groups. Conclusion：The data of our center showed that ICSI did not increase the possibility of abortion and malformation. Therefore,ICSI is an effective method to treat the male factor infertility.