铜绿假单胞菌对哌拉西林/三唑巴坦MIC累积分布的10年监测

Monitoring of Pseudomonas aeruginosa to piperacillin/tazobactam MIC cumulative distribution in 10 years

目的 了解临床分离的铜绿假单胞菌对哌拉西林/三唑巴坦（他唑巴坦）累积最低抑菌浓度（MIC）分布变迁情况,为临床的抗感染与治疗提供借鉴.方法 用WHONET5软件统计分析我院10年铜绿假单胞菌临床分离菌株,用bioLIAISON统计分析哌拉西林/三唑巴坦累积MIC分布变迁情况.结果铜绿假单胞菌的分离率呈逐年上升趋势,从1999年的1.01%上升至2008年的1.46%.哌拉西林/三唑巴坦累积MIC值从1999年至2008年向高值漂移.结论 铜绿假单胞菌的临床分离率在逐年上升,且耐药率呈整体上升趋势,应引起重视,合理使用抗菌药物以降低耐药性已经非常重要.

Objective To understand the change about Pseudomonas aeruginosa to piperacillin/tazobactam MIC distribution isolated and to provide reference for clinical anti-infection and therapy.Methods To analyse Pseudomonas aeruginosaes in our hospital for 10 years with WHONET5 statistical software,and to analyse the changes of piperacillin/tazobactam MIC distribution by bioLIAISON statistical software.Results The isolation rate of Pseudomonas aeruginosa showed an upward shift from 1.01% in 1999 to 1.46% in 2008.Piperacillin/tazobactam MIC values drifted to high-value from 1999 to 2008.Conclusions The clinical isolation rate of Pseudononas aeruginosa increase year by year,and the resistance rate has an overall upward trend.It is important to pay attention to the use of antimicrobial agents to reduce the resistance.