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异氟烷遗忘作用与γ-羟基丁酸受体的关系

Relationship between γ-hydroxybutyric acid receptor and amnesia of isoflurane
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摘要 目的分析异氟烷遗忘作用与γ-羟基丁酸受体(GHBAR)的关系。方法建立异氟烷小鼠遗忘模型,跳台、避暗实验分别观察侧脑室注射不同剂量GHBAR阻断剂NCS-382对模型鼠潜伏期和错误次数的影响。结果NCS-382对异氟烷遗忘作用的影响无统计学意义(P>0.05)。结论GHBAR并非异氟烷遗忘作用的主要靶位。 Objective To investigate the relationship between γ-hydroxybutyric acid receptor（GHBAR） and the amnesia of isoflurane.Methods After the establishment of mice learning and memory model by subcutaneous injection of appropriate doses of isoflurane,different doses of GHBAR antagonist NCS-382 were injected intracerebroventricularly and the effects on the latency period and the number of errors were observed.Results NCS-382 did not have any significant effects on isoflurance-induced amnesia（P〉0.05）.Conclusion GHBAR is not the main target position for isoflurance-induced amnesia.
作者 司振强 张羽 夏雪 郭燕 黄益波 雍辉 周慧轩 周美艳 戴体俊
机构地区 徐州医学院
出处 《江苏医药》 CAS CSCD 北大核心 2010年第7期796-798,共3页 Jiangsu Medical Journal
基金 国家自然科学基金(30872432 30471657 39970715) 江苏省自然科学基金(BK200143)
关键词 异氟烷 NCS-382 学习记忆 Γ-羟基丁酸受体 Isoflurane NCS-382 Learning and memory γ-Hydroxybutyric acid receptor
分类号 R322 [医药卫生—人体解剖和组织胚胎学]
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参考文献10

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江苏医药
2010年 第7期

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