2Levy MM, Fink MP, Marshall JC, et al. 2001 SCCM/ESICM/ AC-CP/ATS/SIS International Sepsis Definitions Conference [J]. Crit Care Med, 2003,31 (4) : 1250-1256.
3Volk HD, Reinke P, Krausch D, et al. Monocyte deactivationrati-onale fora new therapeutic strategy in sepsis[J]. Intensive Care Med, 1996,22(4) : s474-481.
2Volk HD, Reinke P, Krausch D, et al . Monocyte deactivation-rationale for a new therapeutic strategy in sepsis [J]. Intensive Care Med, 1996,22(4): S474-481.
3Oberholzer C, Oberholzer A, Clare-Salzler M, et al .Apoptosis in sepsis: a new target for therapeutic exploration[J]. FASEB J, 2001,15(6): 879-892.
4Oberholzer A, Oberholzer C, Moldawer LL. Sepsis syndromes: understanding the role of innate and acquired immunity [J] . Shock, 2001,16(2) :83-96.
5Hotchkiss RS, Karl IE. The pathophysiology and treatment of sepsis[J].N Engl J Med,2003,348(2): 138-150.
6Baumann CA, Badamchian M, Goldstein AL. Thymosin-alpha1 antagonizes dexamethasone and CD3-induced apoptosis of CD4 + CD8 + thymocytes through the activation of cAMP and protein kinase C dependent second messenger pathways[J]. Mech Ageing Dev, 1997,94(1-3)
7Giuliani C, Napolitano G, Mastino A, et al. Thymosin-alpha1 regulates MHC class I expression in FRTL-5 cells at transcriptional level[J]. Eur J Immunol,2000,30(3) :778-786.
8Jiang X, Kim HE, Shu H, et al .Distinctive roles of PHAP proteins and prothymosin-alpha in a death regulatory pathway[J]. Science,2003,299(5604) :223-226.
9Borzotta AP, Polk HC Jr. Multiple system organ failure. Surg Clin North Am, 1983, 63:315-336.
10Goldstein AL, Low TL, McAdoo M,et al. Thymosin alpha1: isolation and sequence analysis of an immunologically active thymic polypeptide. Proc Natl Acad Sci U S A, 1977, 74:725-729.
3Bruce K, Rubin, Kater AP, et al. Thymosin 4 Seques- ters Actin in Cystic Fibrosis Sputum and Decreases Spu- tum Cohesivity in Vitro[J]. Chest, 2006, 130:1433 - 1440.
4Li YM, Chen H, Li X, et al. A New Immunomodu/atory Therapy for Severe Sepsis: Ulirmstatin Plus Thymosin l[J]. J Intensive Care Med, 2009,24:47-53.
5Ghany MG, Strader DB, Thomas DL, et al.Diagnosis, management, and treatment of hepatitis C : an update[J].Hepatology, 2009,49:1335.
6McCaughan GW, Omata M, Amarapurkar D, et al. Asian Pacific As-so- ciation for the Study of the Liver consensus statements on the di-agno- sis management and treatment of hepatitis C virus infection[J]. JGastro- enterol Hepatol, 2007,22: 615.
7Niederman MS,Mandell LA,Anzueto A,et al.Guidelines for the management of adults with community-acquired pneumonia: diagnosis, assessment of severity, antimicrobial therapy, and prevention[].American Journal of Respiratory and Critical Care Medicine.2001
8American Thoracic Society,Infectious Diseases Society of America.Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia[].American Journal of Respiratory and Critical Care Medicine.2005
9Jiang XJ,Kim HE,Shu HJ,et al.Distinctive roles of PHAP proteins and prothymosin-alpha in a death regulatory pathway[].Science.2003
