赤红活血退黄汤治疗病毒性肝炎高胆红素血症112例临床观察

Clinical Observation of Chihong Huoxue Tuihuang Decoction for Treatment of Viral Hepatitis with Hyperbilirubinemia:A Report of 112 Cases

目的:观察赤红活血退黄汤治疗病毒性肝炎高胆红素血症的临床疗效。方法:将221例患者随机分为治疗组112例与对照组109例,对照组予西药治疗,治疗组在对照组治疗基础上加用赤红活血退黄汤治疗。2组患者治疗前后检测肝功能指标、血清总胆红素(TBil)、直接胆红素(DBil)、谷丙转氨酶(ALT)、谷草转氨酶(AST),观察临床症状变化情况。结果:临床疗效总有效率治疗组为80.36%,对照组为66.97%,2组比较,差异有显著性意义(P<0.05)。治疗后2组的TBil、DBil、ALT、AST均较治疗前显著改善,差异均有非常显著性意义(P<0.01)。治疗后治疗组TBil、DBil改善较对照组明显,差异有显著性或非常显著性意义(P<0.05,P<0.01)。结论:赤红活血退黄汤有明显退黄、降酶作用,其疗效明显优于单纯使用西药治疗。

Objective:To observe the therapeutic effect of Chihong Huoxue Tuihuang Decoction (CHTD) for the treatment of viral hepatitis with hyperbilirubinemia.Methods:Two hundred and twenty-one patients were randomized into 2 groups:the control group (n=109) was given routine western medicine,and the treatment group (n=112) was given routine western medicine and CHTD.The changes of hepatic function,serum total bilirubin(TBil),direct bilirubin (DBil),alanine aminotransferase (ALT),and aspartate aminotransferase(AST)as well as the symptoms were observed in both groups before and after treatment.Results:The total effective rate was 80.36% in the treatment group and 66.97% in the control group(P < 0.05).TBil,DBil,ALT and AST were improved in both groups after treatment(P < 0.01 compared with those before treatment),and the improvement of TBil and DBil in the treatment group was superior to that in the control group (P < 0.05 or P < 0.01).Conclusion:CHTD has an obvious effect on relieving jaundice and decreasing transferase level in treating viral hepatitis with hyperbilirubinemia,superior to western medicine alone.