高血压脑梗死患者血压变异性与血浆内皮素的关系探讨

Relationship between Blood Pressure Variability and Plasma Endothelin in Hypertensive Cerebral Infarction

目的探讨高血压脑梗死患者的血压变异性与血浆内皮素的关系。方法对89例高血压脑梗死患者及39例高血压患者行24h动态血压监测,采静脉血用放射免疫法测定血浆内皮素。结果两组病例的24h平均收缩压、24h平均舒张压、脉压指数(脉压占收缩压比率)相仿,24h收缩压变异性、白昼收缩压变异性、内皮素含量高血压脑梗死组大于高血压组(P值分别为<0.01,<0.05和<0.01),而夜间收缩压变异性及所有舒张压变异性两组间无显著差异。结论血浆内皮素参与EH发生、发展,并加重脑血管的损害。

Objective To study the relationship between blood pressure variability and plasma endothelin in hypertensive cerebral infarction. Methods The 24h blood pressure monitoring was carried out in 89 cases of hypertensive cerebral infarction and 39 cases of essential hypertension,and plasma endothelin was measured with venous blood by radioimmunoassay. Results The two groups showed no significant difference in 24h mean systolic blood pressure, 24h mean diastolic blood pressure and pulse pressure index, and 24h systolic blood pressure variability, daytime systolic blood pressure variabihty and endothelin level in the hypertensive cerebral infarction group were higher than those of the essential hypertension group（P〈0.01 ,P〈0.05 and P〈0.01 ）. Conclusion Plasma endothelin is involved in the occurrence and development of essential hypertension, and can increase the cerebral vascular damage.