乳腺浸润性微乳头状癌的病理及预后分析

Analysis for the pathological diagnose and the prognosis of patients with invasive micropapillary carcinoma of the breast

目的探讨乳腺浸润性微乳头状癌(IMPC)的病理特征及预后分析。方法对14例IMPC组织标本行组织病理和免疫组化检测,观察其病理改变及预后情况。结果14例IMPC病理组织形态学表现为典型的IMPC病理特征。14例乳腺IMPC的免疫表型为ER、PR、c-erbB-2、EMA、CK7、CD31阳性。IMPC与其他浸润性导管癌相比,易出现淋巴结转移(P<0.01),术后易复发转移(P<0.05)。结论IMPC是一种特殊表型的乳腺癌,具有独特的组织形态学特点、免疫组化特征,易发生淋巴转移,预后差,应作为一种独立的乳腺癌亚型加以重视。

Objective To investigate the clinicopathological features,immunophenotype and the prognosis of patients with invasive micropapillary carcinoma of the breast.Methods Among 246 patients with breast invasive ductal carcinoma,14 cases of IMPC were analyzed for those clinical data and pathological features by immunohistochemical method （SP method,for ER,PR,c-erbB-2,EMA,CK7,CD31）.Results The 14 cases of tumors showed typical pathomorphological chracteristics of IMPC.The consistent immunophenotype was found in the 14 IMPC tumors,which were positivity for ER,PR,c-erbB-2,EMA,CK7,CD31.As compared with other breast invasive ductal carcinoma,IMPC showed the features including more lymphatic metastasis and high recurrence rate.Conclusion IMPC is a new subtype of breast carcinoma with unique immunophenotype,distinctive morphological features and poor prognosis.We have to pay much attention to it.