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辛伐他汀治疗高脂血症的临床观察 被引量:10

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摘要 目的观察辛伐他汀治疗高脂血症的疗效和安全性。方法有冠心病及高危因素的高脂血症患者60例,观察治疗前后血脂变化和相关不良反应。结果治疗8周、12周后血清总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)均较治疗前显著下降(P<0.01),三酰甘油(TG)较治疗前明显降低(P<0.05),高密度脂蛋白胆固醇(HDL-C)无显著变化(P>0.05);8周与12周的血脂水平比较差异无统计学意义(P>0.05)。治疗后未出现严重不良反应。结论辛伐他汀治疗高脂血症有较好调脂作用,安全性高,值得在临床推广应用。
出处 《河北医药》 CAS 2010年第8期947-948,共2页 Hebei Medical Journal
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  • 1李光伟,Step.,L.检测人群胰岛素敏感性的一项新指数[J].中华内科杂志,1993,32(10):656-660. 被引量:2125
  • 2Heart Protection Study Collaborative Group. MRC/BHF Heart Protection Study of cholesterol-lowering with simvastatin in 5963 people with diabetes:a randomised placebo-controlled trial[J]. Lancet ,2003,361:2005-2016.
  • 3Sever PS,Dahlof B, Poulter NR,et al. Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial-Lipid Lowering Arm (ASCOT-LLA) : a multicenter randomized controlled trial[J]. Lancet,2003,361:1149-1158.
  • 4Ridker PM. Clinical application of C-reactive protein for cardiovascular disease detection and prevention[J]. Circulation ,2003,107:363-369.
  • 5Ridker PM, Rifai N, Rose L, et al. Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events[J]. N Engl J Med,2002,347:1557-1565.
  • 6Ridker PM, Buring JE, Cook NR, et al. C-reactive protein, the metabolic syndrome, and risk of incident cardiovascular events. An 8-year follow-up of 14,719 initially healthy Americau women[J]. Circulation,2003,107:391-397.
  • 7Ridker PM, Rifai N, Pfeffer M, et al. Long-term effects of pravastatin on plasma concentration of C-reactive protein[ J]. Circulation, 1999,100:230-235.
  • 8Albert MA, Danielson E, Rifai N, et al. Effect of statin therapy on C-reactive protein levels. The Pravastatin Inflammation/CRP Evaluation(PRINCE) :a randomized trial and cohort study[J]. JAMA,2001,286:64-70.
  • 9Strandberg TE,Vanhanen H,Tikkanen M J, Association between change in C-reactive protein and serum lipids during statin treatment[J]. Ann Med,2000,32 :579-583.
  • 10van Wissert S, Trip MD, Smilde TJ, et al. Differential hs-CRP reduction in patients with familial hypercholesterolemia treated with aggressive or conventional statin therapy [J]. Atherosclerosis ,2002,165:361-366.

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