老年胃癌癌前黏膜变化的规律研究

Rules of precancerous gastric mucosa changes in aged patients

目的研究胃癌前黏膜变化的规律。方法对79例老年胃癌患者的胃镜随访资料进行回顾性分析。结果癌前期变化进展至胃癌的平均时间:萎缩性胃炎9.53年,肠上皮化生9.16年,异型增生4.07年,肠上皮化生(中、重度)+异型增生(中、重度)3.89年。胃癌中部分患者并不经历肠上皮化生或异型增生阶段。结论对胃黏膜异型增生和肠上皮化生等病变患者的胃镜随访有利于提高胃癌(特别是早期胃癌)的检出率。

Objective To study the rules of precancerous gastric mucosa changes in aged patients.Methods Gastroscopy data obtained during the follow-up of 79 aged patients with gastric carcinoma were retrospectively analyzed.Results The average progress time of atrophic gastritis,gastric mucosa dysplasia,intestinal metaplasia（moderate and severe） ＋ gastric mucosa dysplasia（moderate and severe） to gastric cancer was 9.53,9.16,4.07 and 3.89 years,respectively.Some gastric cancer patients did not undergo intestinal metaplasia or gastric mucosa dysplasia.Conclusion Gastroscopy and follow-up of patients with intestinal metaplasia or gastric mucosa dysplasia help to detect gastric carcinoma,especially early-stage gastric carcinoma.