胰高糖素样肽-1治疗糖尿病所发生的胰腺炎的争议

Controversy on the diabetic patients with glucagon-like peptide-1 (GLP-1) inducing pancreatitis

胰高糖素样肽-1(GLP-1)由胃肠细胞释放出来的一种激素,能引起胰岛素的释放,降低餐后血糖、胰高糖素的分泌和延缓胃排空。2009年美国食品和药品管理局(FDA)曾报告超过80例的患者因使用GLP-1模拟药物:西他列汀和依森那肽发生胰腺炎,本文就相关问题进行讨论。

Incretin glucagon-like peptide-1 （GLP-1） is a hormone released from cells in the gastroinestinal （GI） tract,leading to glucose-dependent insulin release from the pancreas.It also suppresses postprandial hyperglycemia,glucagon secretion and slows gastric emptying.The US Food and Drug Administration has reported more than 80 cases of pancreatitis associated with GLP-1 mimetic medications：sitagliptin and exenatide in 2009.This article discusses some questions between GLP-1 and pancreatitis.