酮咯酸氨丁三醇与杜冷丁用于胆绞痛镇痛的效果比较

Ketorolac tromethamine and pethidine for biliary colic comparison of analgesic effect

目的以杜冷丁注射液为对照药物观察胆绞痛患者应用酮咯酸氨丁三醇的镇痛效果。方法160例胆绞痛患者(疼痛评分达中或重度疼痛急性疼痛)随机分为4组,每组40例。分别肌肉注射酮咯酸氨丁三醇30mg(A组)、酮咯酸氨丁三醇60mg(B组)、杜冷丁80mg(C组)、杜冷丁40mg+酮咯酸氨丁三醇30mg(D组)每一组都同时肌注654-210mg,行镇痛治疗。由观察者记录药物起效时间及用药前和用药后3h内的疼痛强度、疼痛缓解度、不良反应情况。结果B组疼痛缓解度大于C组(P<0.05)而与D组无明显差别(P>0.05),B组不良反应率比A组无明显提高(P>0.05)。结论肌注酮咯酸氨丁三醇是一种快速、安全、有效、不良反应小的解除胆绞痛的方法,可以代替杜冷丁行胆绞痛治疗。

Objective To pethidine injection as the control drug observation for patients with biliary colic ketorolac tromethamine the analgesic effect.Methods 160 cases in patients with biliary colic （pain rating of moderate or severe pain or acute pain） were randomly divided into four groups,each group 40 cases.Were intramuscular ketorolac tromethamine 30mg （A group）,ketorolac tromethamine 60mg （B group）,pethidine 80mg （C group）,pethidine 40mg ＋ Ketorolac Tromethamine 30mg （D group） were injected in each group were also 654-2 10mg,line analgesic treatment.The onset of drug from the observer records the time and medication before and after treatment within 3h pain intensity,pain relief,adverse reactions.Results B Group C Group is bigger than the pain relief （P〈0.05） with no significant difference between the D group （P〉0.05）,B group of adverse reaction rate than group A no significant increase （P〉0.05）.Conclusion Intramuscular ketorolac tromethamine 60mg is a fast,safe,effective,few side effects way to the lifting of Biliary Colic,Biliary Colic can replace the pethidine line treatment.