醒脑静注射液对重度颅脑损伤患者血浆内皮素影响的研究

Effects of Xingnaojing Injection on Changes of Plasma Endothelin of Patients with Severe Craniocerebral Injury

目的:探讨醒脑静注射液治疗重度颅脑损伤患者血浆内皮素(ET)含量的变化及意义。方法:42例重度颅脑损伤患者被随机分为两组。对照组21例给予常规治疗;治疗组21例在常规治疗基础上于伤后2天给予醒脑静注射液40mL/d,连续用14天。分别于伤后1、3、7和14天采血,用特异性免疫分析法测定血浆中ET的含量,并于治疗前及治疗3天和7天观察两组患者的格拉斯哥昏迷评分(GCS评分)变化。结果:伤后1天两组患者血浆ET含量均较正常参考值明显升高,但两组间比较差异无统计学意义(P>0.05),自伤后3天起两组患者血浆ET含量均呈明显下降趋势,且治疗组明显低于对照组(P<0.05)。治疗后两组GCS评分较治疗前均有所增高,至7天时差异有统计学意义(P<0.05),且治疗组明显高于对照组(P<0.05)。结论:重度颅脑损伤患者血浆ET含量明显升高,与病情轻重有关,醒脑静注射液较常规治疗能更迅速降低血浆ET含量,减轻继发性脑损伤,改善预后。

Objective： To investigate the effects of xing nao jing on changes of plasma endothelin of patients with severe craniocerebral injury.Methods： 42 cases of severe head injury patients were randomly divided into two groups.21 cases of control group were given routine therapy,and 21 cases in treatment group were treated by Xingnaojing injection（40mL per day）consecutively for 14 days additionally.After trauma,on the 1st,3rd,7th and 14th days,blood was collected,respectively.The plasma concentrations of ET were analyzed by radioimmunoassay,and before the treatment and 3 and 7 days after the therapeutic course,the incidence of stress gastric ulcer andthe changes of score of Glasgow Coma Scale（GCS）were observed.Results： The plasma concentrations of ET were increased on the 1st days after treatment I there was no significant difference between the two groups（P〉0.05）.But the plasma concentrations of ET were decreased markedly on the 3rd days in both groups,the values of ET in Xnaojing injection group were significantly more declined than those in control group.Conclusion： The plasma ET levels are increased significantly after severe craniocerebral injury and correlated with the severity of patient 7s condition.Compared with the routine treatment,Xingnaojing injection treatment may obtain better therapeutic results in decreasing plasma ET levels,ameliorating the secondary craniocerebral injury,reducing the incidence of stress gastric ulcer and improving the prognosis.