中药治疗阿尔采末病的分子药理学研究展望

Molecular Pharmacological Research on Traditional Chinese Medicine in the Treatment of Alzheimer's Disease

中药在治疗阿尔采末病中的分子药理学研究已得到广泛开展,一些作用靶点可能指明了目前与将来中药防治阿尔采末病的研究方向。药理学上,这些中药或其有效成分具有胆碱能、抗淀粉样蛋白、抗氧化、抗炎等作用,对阿尔采末病可能具有防治潜力。

Molecular pharmacological progress made in Alzheimer＇s disease （AD） therapy has been reviewed in this article,which describes the latest therapeutic targets and traditional Chinese medicine （TCM） herbs or TCM recipes with cognitive benefits.A variety of active constituents have been further isolated and identified therefore,such as Huperzine AB,Bilobalide,which may elicit multiple molecular pharmacological properties,including antioxidant,cholinergic,anti-beta-amyloidal peptide,anti- inflammatory etc.The survey implies that TCM is a potential pool for innovative research as well as development of pharmaceutical agents and healthcare foods.