9-蒽甲胺的合成

The Synthesis of 9-Aminomethylanthracene

以9-蒽甲醇为原料,通过溴化、叠氮基亲核取代、催化氢化3步反应制备了9-蒽甲胺,总收率达60%。利用1HNMR、质谱、元素分析对产物的组成和结构进行了确认和鉴定。研究结果表明,以Pd/C为催化剂,催化氢化在常温常压下能够快速进行,40min就可完全反应。

9-Aminomethylanthracene is a versatile intermediate in organic synthesis. In this paper it was prepared from 9-anthylmethanol in three steps, including bromination, nucleophilic replacement with azid and Pd/C catalyzed hydrogenation, in 60% overall yield. The hydrogenation finished within 40 min at room temperature and under atmospheric pressure. The structure of the target compound was characterized with ^1H NMR, ESI-MS and elemental analysis.