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图挖掘在DNA混合样本拆分中的应用 被引量：6

Application of Graph Mining in Interpreting DNA Mixtures
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摘要 以图论为基础提出了基于图结构的DNA混合样本拆分算法——MDG算法,对混合STR图谱中每个基因座构造不同的等位基因图,形成等位基因图集,把DNA混合样本的拆分转化为在图集中的挖掘问题。MDG算法的提出进一步扩大了图论的应用范围,也为混合样本拆分提供了新的解决思路。 A lot of instances can be described in graph in real world based on graph theory.The paper proposes an algorithm of separating DNA mixtures-MDG（Mixtures Component Deconvolution using Graph theory）,by which each loci can be construted as some allele graphs.These graphs compose a graph set and convert the problem of separating DNA mixtures into graph mining.The algorithm extends the application of graph theory and proposes a new approach of separating mixtures.
作者 康艳荣 李万水 张国臣 周冬林 楚川红
机构地区 公安部物证鉴定中心
出处 《江南大学学报（自然科学版）》 CAS 2010年第2期210-212,共3页 Joural of Jiangnan University (Natural Science Edition)　
关键词 图 混合样本 峰面积 graph mixtures peak area
分类号 D919.2 [医药卫生—法医学]
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参考文献6

  • 1Clayton T M,Whitaker J P,Sparkes R,et al.Analysis and interpretation of mixed forensic stains using DNA STR profiling[J].Forensic Science,1998,91:55-70.
  • 2Gill P,Sparkes R,Pinchin R,et al.Interpreting simple STR mixtures using allele peak areas[J].Forensic Science,1998,91:41-53.
  • 3Perlin M W,Szabady B.Linear mixture analysis:a mathematical approach to resolving mixed DNA samples[J].Forensic Science,2001,46:1372-1378.
  • 4WANG T,XUE N,Wickenheiser R.Least square deconvolution(LSD):a new way of resolving STR/DNA mixture samples[C].Proceedings of the 13th International Symposium on Human Identification.Phoenix:[s.n.],2002.
  • 5Bill M,Bill P,Curran J,et al.PENDULUM-a guideline-based approach to the interpreation of STR mixtures[J].Forensic Science.2005,148:181-189.
  • 6Buckleton J S,Triggs C M,Walsh S J.Forensic DNA Evidence Interpretation[M].Boca Raton,Florida:CRC Process.2005.

同被引文献33

  • 1I_afountain M J, Schwartz M B, Svete P Aet al. Twgdam validation of the ampfistr profiler plus and ampflstr co- filer STR multiplex systems using capillary electropho- resis[J]. J Forensic Sci,2001, 46(5) :1191-1198.
  • 2Clayton T M, Whitaker J P, Sparkes R, et al. Analysis and interpretation of mixed forensic stains using DNA STR profiling[J]. Forensic Sci Int. 1998, 91(1) : 55-70.
  • 3Martin B, Gill P, Curran J, et al. Pendulum-a guideline based approach to the interpretation of STR mixtures [J]. Forensic Sei Int, 2005, 148(2-3).. 181-189.
  • 4Wang T, Xue N, Birdwell J D. Least-square deconvolu- tiom a framework for interpreting short tandem repeat mixtures[J]. J Forensic Sci, 2006, 51(6):1284-1297.
  • 5Swgdam. Short tanderm repeats (STR) interpretation guidelines[J]. Forensic Sei Comm, 2000, 2(3).
  • 6Mortera J, Dawid A P, Lauritzen S L. Probabilistic ex- pert systems for DNA mixture profiling[J]. Theor Popul Biol. 2003, 63(3):191-205.
  • 7Gill P, Sparkes R, Pinchin R, et al. Interpreting simple SIR mixtures using allele peak areas[J]. Forensic Sci Int, 1998, 91(1) :41-53.
  • 8Perlin MW, Seabady B Linear mixture analysis: a mathe- matical approach to resolving mixed DNA samples[J]. J Forensic Sci, 2001, 46(6) : 1372-1378.
  • 9王静,霍振义,吴春灵,等.似然比率方法计算混合斑[C]//DNA数据库建设应用成果与展望(Ⅲ).北京:中国人民公安大学出版社,2013:189-192.
  • 10Clayton TM, Whitaker JP, Sparkes R, et al. Analysis and inter- pretation of mixed forensic stains using DNA STR profiling [J] : Forensic Sci lnt, 1998,91(1):55-70.

引证文献6

二级引证文献23

江南大学学报（自然科学版）
2010年 第2期

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