环糊精及其衍生物在手性药物分离分析中的应用

application of cyclodextrin and its derivatives in chiral separation and analysis

有近一半的药物具有手性但通常两种异构体并不具有相同的药理活性,有一些异构体甚至具有毒性,因此,采用将手性药物良好分离的分析方法进行质控对药品的质量控制具有重要意义。环糊精及其衍生物是手性药物分离分析中常用的手性添加剂和手性固定相,本文对近年来环糊精及其衍生物在高效液相、气相、毛细管电泳、质谱、超临界流体等方面的应用进行综述。

About half of the drugs in use are chiral,however,that in most cases the pharmacological activity is restricted to one of the enantiomers（eutomer） whereas the other enantiomer（distomer） can be even toxic.The development of methods for enantioselective analysis became very important for drug quality control.Cyclodextrins（CDs） are the most frequently used chiral selectors in chiral separation and analysis.In this paper,the recently application of cyclodextrin and its derivatives were reviewed,which involved HPLC,GC,CE,MS and SFC.