异甘草酸镁治疗抗结核药引起的药物性肝炎临床疗效观察

目的:观察异甘草酸镁治疗抗结核药引起的药物性肝炎临床疗效。方法:将74例抗结核药引起的药物性肝炎患者随机分成治疗组38例和对照组36例,两组均停用抗结核药物。治疗组给予异甘草酸镁治疗,对照组给予还原型谷胱甘肽治疗,疗程2周,观察治疗前后血生化指标的变化。再次予以抗结核用药,且两组护肝用药不变,疗程2周,观察治疗组及对照组血生化指标的变化情况。结果:治疗组患者肝功能好转情况优于对照组(P<0.05)。结论:异甘草酸镁有较好的护肝、降酶作用,未见明显不良反应。

Objective： The goal is observe Magnesium Isoglycyrrhizinate Injection to treat the medicine hepatitis clinical curative effect which the anti - tuberculosis medicine causes. Methods：74 medicine hepatitis patient caused by anti - tuberculosis medicine divides into randomly the treatment group 38 cases and the control group 36 cases, two groups stop using the anti - tuberculosis medicine, the treatment group was given Magnesium Isoglycyrrhizinate Injection treatment, the control group return to original state Gu Guanggan the peptide treatment, the treatment course is 2 weeks, observe the blood biochemistry target change; Gives the anti - tuberculosis medicine once more ,and protect the liver medication to be invariable, treatment course 2 weeks, observation treatment group and control group blood biochemistry target change situation. Results：Treatment group patients liver function change for the better situation surpasses the control group （ P 〈 0. 05 ）. Conclusion： Magnesium Isoglycyrrhizinate Injection has well protects the liver, fails the enzyme action, has not seen responded not good.