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梅毒螺旋体分子流行病学研究进展 被引量：5

Progress in molecular epidemiology of syphilis
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摘要 梅毒的流行已经成为全世界重要的公共卫生问题之一。梅毒螺旋体分型系统的研究,几十年来一直是各国学者致力攻克的难题。直到20世纪90年代末,美国疾病控制与预防中心(CDC)首次提出了操作简便、具有实用性的基因分型系统,从而使得对梅毒分子流行病学的研究进入崭新的发展时期。该文对这一分型系统的特征和梅毒螺旋体分子流行情况进行综述。 Syphilis epidemic has become one of the important public health problems throughout the world. However,the molecular system for typing of Treponema Pallidum had not been developed until the late 1990s when a simple practical molecular typing system was developed and introduced by US CDC. With this technology,a large number of studies on molecular epidemiology of syphilis have been conducted. This paper reviews the characteristics of this typing system and the prevalence of syphilis in the recent years.
作者 彭锐锐 李婧 陈祥生
机构地区 中国医学科学院北京协和医学院皮肤病研究所
出处 《中国艾滋病性病》 CAS 2010年第2期192-194,共3页 Chinese Journal of Aids & STD
关键词 梅毒螺旋体 酸性重复蛋白基因 梅毒螺旋体重复基因家族 基因分型 分子流行病学 Treponema Pallidum Arp Tpr Molecular typing Molecular Epidemiology
分类号 R377.1 [医药卫生—病原生物学]
  • 相关文献

参考文献31

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二级参考文献14

  • 1曾铁兵,吴移谋,黄澍杰,吴志周.衡阳和江门地区梅毒螺旋体基因分型的初步研究[J].中华皮肤科杂志,2004,37(12):692-694. 被引量：14
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共引文献35

同被引文献62

  • 1曾铁兵,吴移谋,黄澍杰,吴志周.衡阳和江门地区梅毒螺旋体基因分型的初步研究[J].中华皮肤科杂志,2004,37(12):692-694. 被引量：14
  • 2郑和平,欧志英,胡玉山,黄进梅,李美玲,吴兴中,曾维英,潘慧清.梅毒螺旋体的巢式PCR检测与基因分型[J].中华皮肤科杂志,2005,38(9):546-548. 被引量：22
  • 3Febbrao I, Mabetti G, Balestrieri P, et al. Rectal cancer or rectal chancre Beware of primary syphilis[J]. Digestive and Liver Disease, 2008,40(7) : 579-581.
  • 4Buchacz K, Patel P, Taylor M,et al. Syphilis increases HIV viral load and decreases CD4 cell counts in HIV-infected patients with new syphilis infections. AIDS, 2004,18:2075- 2079.
  • 5Pillay A, Liu H, Chen CY, et al. Molecular subtyping of Treponema pallidum subspecies pallidum. Sex Transm Dis,1998,25:408-414.
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  • 8Liu H, Rodes B, George R,et al. Molecular characterization and analysis of a gene encoding the acidic repeat protein (Arp) of Treponema pallidum. J Med Microbiol, 2007,56: 715-721.
  • 9Harper KN, Liu H, Ocampo PS, et al. The sequence of the acidic repeat protein (arp) gene differentiates venereal from nonvenereal Treponema pallidum subspecies, and the gene has evolved under strong positive selection in the subspecies that causes syphilis. FEMS Immunoi Med Mierobiol, 2008, 53,322-332.
  • 10Giacani I J, Molini B, Godornes C, et al. Quantitative analysis of tpr gene expression in Treponema pallidum isolates: Differences among isolates and correlalion with T- cell responsiveness in experimental syphilis. Infect Immun, 2007,75 : 104-112.

引证文献5

二级引证文献5

中国艾滋病性病
2010年 第2期

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