艾司西酞普兰治疗广泛性焦虑症的临床研究

A clinical study of escitalopram in the treatment of generalized anxiety disorder

目的:评价艾司西酞普兰治疗广泛性焦虑症的临床疗效和安全性。方法:对符合入组标准的广泛性焦虑症患者服用艾司西酞普兰,疗程8周,并用汉密尔顿焦虑量表(HAMA)、临床疗效总评量表(CGI)、药物不良反应评定量表(TESS)分别在治疗前、治疗第2、4、6、8周进行评分。依据HAMA总分减分率判定疗效。结果:治疗第2周起,HAMA评分,CGI评分与治疗前相比均有显著下降(p<0.01),治疗第8周有效率为80.49%。不良反应最常见的是食欲下降(14.63%),其次恶心(7.32%),但不影响正常治疗。结论:艾司西酞普兰治疗广泛性焦虑症有效、安全,不良反应轻。

Objective ：To exlore clinical efficacy and safety of esoitalopram in the treatment of generaliized anxiety disorder. Methods：The patients who accorded with the inclusion criteria were administered with escitalopram for 8 weeks, and evalulated with Hamilton Depressive Scale （HAMD）, Clinical Global Impression Scale （CGI） ,and Treatment Emergent Symptom Scale （TESS） before treatment and 2,4,6,8 weeks after treatment. The effects was assessed by the reducing score rate of general score of HAMD. Results： HAMD scores and CGI scores decreased dramatically from the second week （ p 〈 0.01 ）, the response rate was 80.49 % after 8 week treatment. The most common adverse reaction was lack of appetite （ 14.63% ） ,whereafter nausea （7.32%）, but no effects on the common treatment. Conclusion：Escitalopram is effective and safe as well as less adverse reaction in the treatment of generallized anxiety disorder.