热休克蛋白27与缺血-再灌注损伤关系的研究进展

Progress in the relationship between heat shock protein 27 and ischemiareperfusion injury

热休克蛋白27是细胞在应激状态下产生的一种小分子蛋白，具有高度保守性，在抗缺血-再损伤中发挥重要作用。随着器官移植技术的不断提高，心脏、肝脏、肾脏等器官移植越来越多，器官的缺血-再灌注损伤成为移植物存活与否的一个不可忽视的环节，研究内源性的器官保护机制，显得尤为重要。本文就热休克蛋白27与缺血-再灌注损伤的关系作一综述。

Heat shock protein 27 is a small kind of protein which is produced under stress. HSP 27 is highly conservative, and plays an important role in ischemia-reperfusion injury. With the development of organ transplantation technique, the transplantation of heart,liver, kidney becomes more and more popular, the isehemia-reperfu-sion injury is a significant part of the management of these procedures. The endogenic research against the injury becomes more vital. This article is the first review of the relationship between heat shock protein 27 and isehemiareperfusion injury.