尿微量白蛋白检测在高血压病及糖尿病肾病诊断中的应用

Application of Detection of Albumin in the Diagnosis of Hypertensive and Diabetic Nephropathy Disease

目的探讨尿微量白蛋白测定在高血压病及糖尿病肾病中的应用价值。方法将研究对象分为高血压病组(63例)、糖尿病组(40例)、糖尿病肾病组(42例)、高血压合并糖尿病组(48例)及健康对照组(45例),检测其晨尿中微量白蛋白的含量和血中尿素氮、肌肝的含量。结果①高血压病组、糖尿病组、糖尿病肾病组及高血压合并糖尿病组中尿微量白蛋白与对照组比较,差异均有显著性(P<0.01)。②糖尿病组、高血压组及高血压合并糖尿病组中尿微量白蛋白依次增高。结论①肾功能损害与血压水平有关。②高血压比血糖更容易加重患者肾脏损害。③高血压病及糖尿病患者应进行尿微量白蛋白含量的筛查,这有利于糖尿病患者肾病及其心血管并发症的早期预防和干预治疗。

Objective To observe the clinical value of detection of urine minimum albumin in diagnosis of hypertensive and diabetic nephropathy disease.Methods All the case were divided into five groups：hypertensive disease group（n=63）,diabetic group（n=40）,diabetic nephropathy group（n=42）,hypertensive disease complicating high blood gulcose group（n=48） and healthy controls（n=45）.Determination of the urine minimumalbumin,urea nitrogen of blood and creatininein of blood in all the case was made.Results ①The concentration of urine minimumalbumin of hypertensive disease group,diabetic group,diabetic nephropathy group and hypertensive disease complicating high blood gulcose group was significant difference as compared with that of healthy controls（P0.01）.②The concentration of urine minimumalbumin increased in diabetic group、hypertensive disease and hypertensive disease complicating high blood gulcose group.Conclusion①The impairment of renal function is relevant with the level of blood pressure.②Compared with high blood glucose,high pressure aggravate the impairment of renal function easily.③The determination of concentration of urine minimum albumin in diabetic patient is useful for early diagnosis and intervention of hypertensive group and diabetic disease group.