血浆OPN和TAT水平检测在非小细胞肺癌中的临床意义

Plasma levels of TAT and OPN in non-small cell lung cancer

目的探讨骨桥蛋白(OPN)、凝血酶抗凝血酶复合物(TAT)在非小细胞肺癌(NSCLC)血浆中水平的临床意义。方法采用ELASA法检测46例NSCLC、22例肺部良性病变患者及20例健康体检者血浆TAT、OPN水平。比较各组数据之间关系。结果 OPN在NSCLC血浆水平明显高于肺部良性病变患者及健康体检者(t=7.376,P=0.017);TAT在NSCLC血浆水平明显高于肺部良性病变患者及健康体检者(t=15.885,P=0.000)。而肺部良性病变患者及健康体检者对比,差异无统计学意义;OPN、TAT血浆水平与肺癌分期、远处转移呈正相关(r=0.502,P<0.05);与年龄、性别相关性无统计学意义。结论 TAT、OPN可作为分期及转移的指标,且二者可能在NSCLC发生发展方面具有协同作用。

Objective To study the plasma levels of thrombin-antithrombin complex（TAT） and osteopontin（OPN） in non-small Cell Lung Cancer（NSCLC）.Methods The plasma levels of TAT and OPN were determined by ELASA in 46cases of NSCLC patients,22 patients with benign pulmonary disease and 20 health people.Results Plasma levels of OPN,TAT in group of NSCLC were higher than those with benign pulmonary disease and health（P0.05）,but there were no significant difference between benign pulmonary disease and health group（P0.05）.The plasma levels of OPN and TAT were correlated with TNM stage and distant metastasis（P0.05）,but the plasma levels of OPN and TAT were not correlated with gender and age（P0.05）.Conclusion TAT and OPN are closely correlated with invasion and metastasis in NSCLC.TAT and OPN might play synergetic role in carcinogenesis and progression of NSCLC.