6,7-二(2-甲氧基乙氧基)喹唑啉-4-酮的合成

Synthesis of 6,7-Bis(2-methoxyethoxy)quinazolin-4(3H)-one

以3,4-二羟基苯甲酸乙酯为原料,通过醚化、硝化、还原、成环四步反应合成新型抗癌药物中间体6,7-二(2-甲氧基乙氧基)喹唑啉-4-酮,改进了工艺,考察了各类工艺条件对目标产物收率的影响,得到最适宜反应条件,在优化条件下,总收率为83.7%。

6,7-Bis（2-methoxyethoxy）quinazolin-4（3H）-one was prepared through etherification,nitration,reduction and cyclization from the starting material ethyl 3,4-dihydroxybenzoate.The synthetic process was improved,and the optimum conditions for the reaction were determined with an overall yield of 83.7%.