Saquinavir mesylate的不对称合成研究进展

Research Progress of Saquinavir mesylate in the Asymmetric Synthesis

综述了治疗艾滋病药物Saquinavir mesylate的研究概况,对Saquinavir mesylate的不对称合成方法进行了归纳和总结,重点介绍了不对称还原、不对称醇醛缩合和Sharpless环氧化等反应在Saquinavir mesylate不对称合成中的应用。对今后Saquinavir mesylate不对称合成的研究动向进行了展望。

Research on HIV protease inhibitor Saquinavir mesylate has been reviewed.The main asymmetric synthetic methods of Saquinavir mesylate are summarized with the emphasis on applications of asymmetric reduction,asymmetric aldol condensation and Sharpless asymmetric epoxidation reaction in the asymmetric synthesis of Saquinavir mesylate.The future trends in the asymmetric synthetic research on Saquinavir mesylate are outlined.