环糊精超分子水凝胶

Cyclodextrin-Containing Supramolecular Hydrogels

本文综述了近年来基于环糊精包合作用的超分子水凝胶的研究进展,主要包括:环糊精与线性、星型、接枝、超支化聚合物包合形成的多聚(准)轮烷自组装制备超分子物理凝胶及功能化多聚(准)轮烷经交联反应制备超分子化学凝胶;环糊精、环糊精二聚体及其水溶性聚合物与带疏水性侧基的聚合物经"锁-钥匙"包合作用形成超分子物理凝胶;及其在药物、基因释放载体与组织工程支架中的应用。着重介绍了剪切、温度、pH值、光等刺激-响应性超分子水凝胶的设计与制备。

Recent progresses in studies on supramolecular hydrogels based on the inclusion complexation of cyclodextrins with various guest molecules are reviewed, mainly including： （1） the supramolecular physical hydrogels formed from the self-assembly of poly （ pseudo ） rotaxanes between cyclodextrins and different polymers such as linear, star-shaped, graft, or hyperbranched ones, and the supramolecular chemical hydrogels formed via the crosslinking reaction of functionalized poly（pseudo） rotaxanes ; （2） the supramolecular physical hydrogels based on the formation of inclusion complexes via ＂lock and key＂ as physical crosslinking points between cyclodextrins, their dimers or water-soluble cyclodextrin-containing polymers and polymers with hydrophobic side groups and their potential applications as drug/gene delivery carriers and tissue engineering scaffolds. This review was focused on the design and preparation of the supramolecular hydrogels with stimuli-responsive properties including shear, temperature, pH, light, etc.