摘要
本文综述了近年来基于环糊精包合作用的超分子水凝胶的研究进展,主要包括:环糊精与线性、星型、接枝、超支化聚合物包合形成的多聚(准)轮烷自组装制备超分子物理凝胶及功能化多聚(准)轮烷经交联反应制备超分子化学凝胶;环糊精、环糊精二聚体及其水溶性聚合物与带疏水性侧基的聚合物经"锁-钥匙"包合作用形成超分子物理凝胶;及其在药物、基因释放载体与组织工程支架中的应用。着重介绍了剪切、温度、pH值、光等刺激-响应性超分子水凝胶的设计与制备。
Recent progresses in studies on supramolecular hydrogels based on the inclusion complexation of cyclodextrins with various guest molecules are reviewed, mainly including: (1) the supramolecular physical hydrogels formed from the self-assembly of poly ( pseudo ) rotaxanes between cyclodextrins and different polymers such as linear, star-shaped, graft, or hyperbranched ones, and the supramolecular chemical hydrogels formed via the crosslinking reaction of functionalized poly(pseudo) rotaxanes ; (2) the supramolecular physical hydrogels based on the formation of inclusion complexes via "lock and key" as physical crosslinking points between cyclodextrins, their dimers or water-soluble cyclodextrin-containing polymers and polymers with hydrophobic side groups and their potential applications as drug/gene delivery carriers and tissue engineering scaffolds. This review was focused on the design and preparation of the supramolecular hydrogels with stimuli-responsive properties including shear, temperature, pH, light, etc.
出处
《化学进展》
SCIE
CAS
CSCD
北大核心
2010年第5期916-926,共11页
Progress in Chemistry
基金
国家重点基础研究发展计划(973)项目(No.2009CB526402)
湖北省自然科学基金项目(No.2007ABB033)资助
关键词
环糊精
包合作用
多聚(准)轮烷
超分子水凝胶
刺激.响应性
cyclodextrins
inclusion complexation
poly (pseudo) rotaxanes
supramolecular hydrogels
stimulus -response