壳聚糖含磷衍生物的合成、表征及其应用研究

Synthesis,Characterization and Application of Phosphorus-Containing Derivatives of Chitosan

壳聚糖是一种可再生的天然碱性多糖,具有多种优良的特性。但是,由于壳聚糖本身的溶解性很差,只能溶解在一些稀酸中,这就在一定程度上限制了其进一步的研究与应用。因此,通过修饰改性提高其已有功能、赋予新的功能是壳聚糖重要的研究领域。其中,通过磷酸化或磷酰化改性是壳聚糖改性研究的方向之一。本文综述了在壳聚糖链上引入含磷/膦基团合成壳聚糖含磷衍生物的研究进展;介绍并讨论了壳聚糖含磷衍生物的合成及纯化方法;对壳聚糖含磷衍生物结构、性能及表面形貌的表征进行了详细的阐述;对壳聚糖含磷衍生物的应用进行了总结,并展望了壳聚糖含磷衍生物未来的应用前景。

Chitosan is a renewable and natural basic polysaccharide with a variety of excellent features. However,since the dissolution of chitosan is poor, it can only be dissolved in some dilute acids, which restricts its further research and application. Therefore, to exploit the unique properties and to realize the full potential of the versatile polysaccharides, attempts are being made to chemically modify them. Phosphorylation or phosphoryl modification of chitosan is one of the methods. In this paper, introducing phosphorus-containing groups into chitosan to form phosphorus-containing derivatives are reviewed. And their synthesis and purification methods, characterization of the structure, properties and applications are presented and discussed detailedly. Finally, the opinions with respect to prospects of phosphorus-containing derivatives of chitosan are proposed.