人参皂甙Rb1对抗运动性骨骼肌疲劳的实验研究

Experimental Study on Ginsenoside Rb1 Against Exercise-Induced Skeletal Muscle Fatigue

目的为了降低自由基的强氧化性导致的运动性骨骼肌疲劳。方法本文主要运用文献资料法、实验法和数理统计法,对运动性疲劳模型大鼠骨骼肌超氧化物岐化酶(SOD)活性以及骨骼肌丙二醛(MDA)的含量进行检测。结果与模型组比较,人参皂甙Rb1能有效的降低MDA含量,提高SOD活性;人参皂甙Rb1有效提高机体的抗氧化酶(SOD)活性水平、达到抗运动性疲劳的机制可能有两种,一是能够直接参与机体清除自由基离子的能力,二是通过减少氧化还原反应的底物浓度,进而影响酶活性来实现。结论人参皂甙Rb1具有对抗大强度运动时所产生的自由基,减缓运动性骨骼肌疲劳的作用。

Objective In this paper,in order to reduce the strong oxidizing free radicals caused by exercise-induced skeletal muscle fatigue.Methods The model of exercise-induced fatigue in skeletal muscle superoxide dismutase（SOD） skeletal muscle activity and malondialdehyde（MDA） levels were detected by use of literature and data,experimental method and mathematical statistics.Results The results showed that compared with model group,ginsenoside Rb1 could effectively reduce the MDA content and increase SOD activity;ginsenoside Rb1 effectively enhanced the body＇s antioxidant enzyme（SOD） activity levels,and there might be two mechanisms reaching anti-exercise-induced fatigue-one is to directly participate in ion-free radical scavenging ability of the body,and the other is to affect enzyme activity by reducing the redox reaction of substrate concentration.Conclusions Therefore,ginsenoside Rb1 against high-intensity exercise has generated free radicals and slowed down the role of exercise-induced skeletal muscle fatigue.