甲型H1N1流感儿童发生呼吸衰竭的危险因素分析

To evaluate hish risk factors contribute to respiratory failure in children with novel influ- enza A （ H1N1 ） virus infection

目的探讨儿童甲型H1N1流感患者发生呼吸衰竭（acute respiratory failure，ARF）的危险因素，为针对性预防其发生提供临床依据。方法对2009年9月至2010年1月我院住院51例甲型H1N1流感儿童的资料进行回顾性分析。结果51例儿童甲型H1N1流感患儿，5例发生呼吸衰竭，发生率为9．80％，多元回归分析最近有呼吸道感染或使用免疫抑制剂、中性粒细胞计数〉70％，具有统计学意义（P〈0．05），均为独立的危险因素。结论甲型H1N1流感儿童必须预防或积极治疗其合并的细菌感染，以防呼吸衰竭的发生。

Objective To evaluate high risk factors contribute to acute respiratory failure （ ARF ） in children with novel influenza A （ H1N1 ） virus infection, btethods 51 children（ ≤ 14 years old ） with novel influenza A （ H1N1 ） virus infection were enrolled from 2009-9-19 to 2010-1-31. To collect the clinical data and restrospective analysis was used in this study. Basulta 5 cases complated with respiratory failure. The incidence of respiratory failure in children with novel influenza A（ H1N1 ）virus infection in our hospital is 9.80%. Throught Logistic regression analysis , there are high risk factors insreasing children with novel influenza A （ H 1N 1 ） virus infection liability to respiratory failure： recent respiratory tract infection or use of immunosuppressive agents; neutrophil cell count 〉 70%. Conuaiona In children with novel influenza A （ H1N1 ） virus infection, respiratory tract infection should be prevented and treated actively in order to prevent respiratory failure.