依匹斯汀与蜈黛软膏联合液氮冷冻治疗慢性湿疹疗效观察

Efficacy of epinastine with centipede and natural indigo mix ointment combined with liquid nitrogen refrigerafion in the treatment of chronic eczema

目的观察依匹斯汀与蜈黛软膏联合液氮冷冻治疗慢性湿疹的疗效。方法将80例慢性湿疹患者随机分成治疗组和对照组，治疗组口服依匹斯汀片，每次20mg，每日1次，外用蜈黛软膏，每日早晚各1次，同时联合液氮冷冻治疗，苔藓样变皮损冷冻治疗时间需延长至皮损颜色变白，然后复温，间隔两分钟再治疗1次，一般冻融1．2次，皮损颜色变为紫黑色为宜，剩余皮损冷冻治疗隔日1次；对照组口服依匹斯汀片，每次20mg，每日1次，外用糠酸莫米松软膏，每日1次，两组疗程均为1个月。结果治疗组总有效率为92．5％，对照组总有效率为72．5％，两组比较差异有显著性（P〈0．05）。结论依匹斯汀与蜈黛软膏联合液氮冷冻治疗慢性湿疹疗效确切，副作用小，患者易耐受，值得在临床上推广使用。

Objective To observe the efficacy of epinastine with Centipede and natural indigo mix ointment combined with liquid nitrogen refrigeration in the treatment of chronic eczema. Methods Eighty patients of chronic eczema were divided into 2 groups randomly. The treatment group were treated with oral epinastine once 20mg, once perday. Also, topical the centipede and natural indigo mix ointment was used twice daily, combined with liquid nitrogen refrigeration to treat once every other day in the treatment group. The lichenification of chronic eczema require an extension of time to turn white for treatment of refrigeration, then to rewarming, which was also treated for interval of 2 minutes. The lichenification would be to turn purplish black of refrigeration treatment for one or two times. The control group was treated with oral epinastine once 20rag, once perday. Besides, topical cream mometasone furoate was also used once perday. The two groups were treated for a month. Results The total effective rate of treatment group and control group were 92.5% and 72.5% respectively. There is a significant difference between the two groups （ F〈 0.05 ）. Coneluaion Epinastine with centipede and natural indigo mix ointment combined with liquid nitrogen refrigeration is a safe and effective alternate means to treat chronic eczema.