^(131)I治疗后Graves病突眼与甲亢病情转归相关分析

Association analysis of exophthalmos and turnover of state on Graves disease after ^(131)Iodine therapy

目的分析131I治疗后Graves病患者突眼与病情转归的关系。方法将进行131I治疗的Graves病患者分为突眼组和无突眼组,并分析两组131I治疗后甲亢及突眼病情转归情况。结果突眼组及无突眼组131I治疗有效率、永久性甲减发生率及治疗无效率相比均有统计学差异(P均<0.05)。突眼组患者131I治疗后总有效率为73.5%(72/98例),甲亢治疗有效的67例患者中,突眼治愈及好转者56例,占83.6%。突眼组促甲状腺受体抗体水平明显高于无突眼组(P<0.05)。结论 131I是治疗Graves病患者甲亢及突眼的有效方法,突眼治疗效果与甲亢病情转归密切相关。

Objective To analyse the association of exophthalmos and turnover of state on Graves disease patients after 131Iodine therapy.Methods The cases with Graves disease,divided into exophthalmos group and no exophthalmos group,were analyzed about the association of exophthalmos and turnover of state on Graves disease after 131Iodine therapy.Results The effective rate of no exophthalmos group was significantly higher than that of exophthalmos group（P0.05）.The rate of permanent hypothyroidism of no exophthalmos group was also significantly higher than that of exophthalmos group（P0.05）.The total effective rate of exophthalmos group after 131Iodine therapy was 73.5%（72/98 cases）.The effective rate of exophthalmos was 83.6%（56/67 cases） in which cases with effective treatment of hyperthyroidism.The levels of TRAb in exophthalmos group were higher than thoses in no exophthalmos group.There was a significant difference between the two groups（P0.05）.Conclusions 131Iodine therapy was effective for hyperthyroidism and exophthalmos on Graves disease.There was close relation between the therapy effect of exophthalmos and hyperthyroidism.