首发和复发双相情感障碍患者血浆非酶类抗氧化剂的比较研究

Plasma non-enzymatic antioxidants in first onset and recurrent bipolar disorder patients:a comparative study

目的比较首发和复发双相情感障碍患者血浆非酶类抗氧化剂的差异。方法对30例首发双相情感障碍患者、49例复发患者、42例正常对照者进行血浆非酶类抗氧化剂(清蛋白、尿酸、总胆红素)的检测。结果首发和复发双相情感障碍患者血浆非酶类抗氧化剂的差异无统计学意义;首发双相情感障碍组胆红素比对照组低,复发双相情感障碍组清蛋白、胆红素比对照级低,差异有统计学意义。复发双相情感障碍患者血浆中3种非酶类抗氧化剂和病程及情感障碍发作次数没有相关性。结论首发和复发双相情感障碍患者均存在抗氧化系统的失调并进一步导致氧化应激,这种氧化应激可能在双相情感障碍的发病初期就存在,和药物治疗、病程及情感障碍发作次数无关。

Objective To explore the difference of plasma non-enzymatic antioxidants between first onset and recurrent bipolar disorder（BD）patients. Methods A total of 30 first onset BD patients, 49 recurrent BD patients and 42 healthy subjects （as the controls） were investigated. The plasma non-enzymatic antioxidants （albumin, uric acid and total bilirubin） were examined in their plasma samples. Results The non-enzymatic antioxidants levels in the first onset and recurrent BD groups were not significantly different. The total bilirubin level of the first onset BP group was significantly lower than that of the control group, and the albumin and total bilirubin in the recurrent BP group were significantly lower than those of the control group. The levels of 3 types of non-enzymatic antioxidants in the recurrent BD group were not correlated with the disease duration and the number of recurrent episodes. Conclusions Both first onset and recurrent BD patients have antioxidant defense system （AODS） disorder. The defect in the AODS, which may lead to oxidative damage, occurs early in the course of illness and is independent of the treatment, the duration and the number of recurrent episodes.