摘要
目的制备依巴斯汀口服溶液并建立其质量控制方法。方法以依巴斯汀为主药,β-环糊精为辅料制备口服溶液。采用高效液相色谱法测定依巴斯汀的含量。结果依巴斯汀在10～100mg·mL-1范围内线性关系良好(r=0.9998),平均回收率为98.99%(RSD=1.06%,n=3)。结论该口服溶液制备简单且质量可控。
OBJECTIVE To prepare ebastine oral solution and establish a method tor its quality control. METHODS Ebastine and β-cyclodetrin were used as main compositions. The content of ebastine was determined by HPLC spectrophotometry. RESULTS The linear range of ebastine was 10-100 mg·L^-1（r = 0. 9998）, and the average recovery was 98.99 % （ RSD = 1.06 %, n = 3）. CONCLUSION The preparation of ebastine oral solution is simple, and the quality can be controlled.
出处
《海峡药学》
2010年第4期53-54,共2页
Strait Pharmaceutical Journal
关键词
依巴斯汀
口服溶液
制备
质量控制
ebastine
oral solution
preparation
quality control
