新型长效干扰素α_(2b)对恒河猴的毒性研究

Toxicity Study of New Long-acting Interferon α_(2b) in Rhesus Monkey

目的观察白蛋白-干扰素融合蛋白Woferon皮下注射给药对恒河猴的毒性作用。方法恒河猴皮下注射Woferon5周毒性试验,观察给药后动物的临床行为、心电图、外周血象、血液生化、尿液等指标的变化。结果恒河猴皮下注射高剂量(800μg/kg)Woferon引起可逆性白细胞(WBC)下降(P<0.05)和天冬氨酸转氨酶(AST)、丙氨酸转氨酶(ALT)升高;高剂量组(800μg/kg)、中剂量组(200μg/kg)恒河猴产生可逆的血小板(Plt)下降(P<0.05)。结论Woferon给恒河猴皮下注射5周除有一过性外周血WBC、Plt下降外,未见其他明显毒性反应。

Objective To observe the toxic effects of the new type of albumin-interferon Woferon in Rhesus monkeys.Methods Subcutaneous injection of Rhesus monkeys Woferon for 5 weeks,the animals＇ behavior,electrocardiogram（ECG）,hematology,biochemistry and urine were observed.Results The subcutaneous injection of high-dose Woferon（800 μg/kg）,rhesus monkeys cause white blood cells（WBC）decrease（P0.05）and aspartate aminotransferase（AST）,and alanine aminotransferase（ALT）increase.In the high-dose group middle dose group（200μg/kg）rhesus monkeys had a reversible platelet（Plt）decrease（P0.05）.Conclusion Woferon subcutaneous injection to rhesus monkeys for five weeks will cause the revisable decrement of WBC Plt,and no other significant toxicity occurs.