肿瘤电化学疗法的主要治疗电参数的计算

ELECTROCHEMOTHERAPY OF TUMOR: CALCULATION OF MAIN ELECTRIC PARAMETER IN TREATMENT

本文根据电化学治疗肿瘤的机理，讨论了电极间ｐＨ梯度场及电流密度分布对治疗效果的影响，导出了电极最小有效治疗电流密度的计算公式，进而由电极针上应该通过的最小有效治疗电流的公式。在此基础上，本文根据电化学治癌时在电极间建立必要的ｐＨ梯度场所需要的时间和癌细胞死亡的平均半衰期，导出了电化学治癌所需要的有效治疗时间和有效治疗剂量的计算公式。这样本文就为临床治疗中确定有效治疗电流和有效治疗剂量的大小，为选择电极间距等提供了一种理论根据。

n the basis of mechanism of treating tumor in electrochemistry, influence of distribution of pH gradient field between the electrodes was discussed as well as uniformity of distribution of current density on the treatment effect. Formula of calculating the minimum current density of electrode in effective therapy was set forth, as well as formula of minimum curable current passing per unit length on electrode needle. On the basis of these data, according to the time needed to set up necessary pH gradient field between electrodes in electrochemotherapy of tumor, as well as average halflife of cancer cell death, formulas to calculate effective treatment time and dose are obtained, thus providing theoretical foundation of fixing effective treatment current and dose and distance between electrodes in clinical therapy.