摘要
目的探讨硝苯地平与肺泡液体清除率(AFC)之间的关系,进一步阐明硝苯地平所致非心源性肺水肿发生的病理生理学机制。方法应用酶标仪测定小牛血清白蛋白浓度的方法测定小鼠在体AFC。结果硝苯地平气管内给药对AFC无明显抑制作用,为(49±5)%。结论临床上硝苯地平引起的非心源性肺水肿可能不是通过调节肺泡上皮钠主动转运机能,抑制肺水肿液的吸收而起作用的。
Objective Noncardiogenic pulmonary edema is a known side effect of calcium channel blockers.Acute pulmonary edema following oral tocolytic nifedipine has been reported and the underlying mechanisms have not been completely explored.We aim to explore the relationship between nifedipine and alveolar fluid clearance（AFC） and to find the pathophysiologic mechanism of noncardiogenic lung edema.Methods In vivo AFC was measured using bovine serum albumin protein assays.Results The rate of in vivo AFC was not significantly reduced in mice intratracheally administrated nifedipine[（49±5）%].Conclusion Our observations demonstrate that nifedipine may cause noncardiogenic lung edema by ways other than affecting alveolar fluid clearance.
基金
国家自然科学基金(30971181)
关键词
硝苯地平
肺水肿
钠通道
肺泡液体清除率
Nifedipine
Pulmonary edema
Sodium channel
Alveolar fluid clearance
