参附注射液对重型颅脑损伤的辅助治疗作用

The effect of Shenfu injection as adjunctive therapy in patients with severe head injury

目的:探讨参附注射液对重型颅脑损伤患者的脑保护作用。方法:将72例重型颅脑损伤患者随机分成参附治疗组(38例)及对照组(34例)。对照组予以脱水、激素、止血、抗感染等常规治疗,参附治疗组在常规治疗基础上,在伤后早期给予参附注射液3 mL/kg,分3次,连续使用10 d。所有患者行颅内压监测,观察两组患者的最高颅内压、觉醒天数,甘露醇使用天数及剂量,并发症并对预后评估。结果:参附治疗组最高颅内压平均为(22±12)mmHg,对照组为(26±9)mmHg;脱水剂应用时间参附组为(6±3)d,对照组为(7±5)d;脱水剂应用剂量参附组为(770±125)g,对照组为(1045±225)g;平均清醒时间参附组为(9±4)d,对照组为(11±4)d。以上各项于两组比较均有显著性差异(P<0.05)。结论:参附注射液对重型颅脑损伤具有一定的脑保护作用。

Aim：To discuss the brain protection of Shenfu injection in the patients with severe head injury.Methods： Seventy-two patients were randomly divided into two groups.In the controlled group,patients had received the routine therapy,whereas patients in the Shenfu group took the routine therapy and Shenfu Injection with dose 1 mL/kg,tid for 10 days.All patients were monitored for the intracranial pressure（ICP）.The highest ICP,days of coma,dosage and days of using mannitol,complications,and prognosis in comparing between the two groups.Results： The mean value of the highest ICP were（22±12）mmHg and（26±9）mmHg in the Shenfu group and the controlled group respectively.Patients in Shenfu group used mannitol for（6±3）d,comparing to（7±5）d in controlled group.Mean duration of coma in patients of Shenfu group was（9±4）d,comparing to（11±4）d in Controled group.There were significant differences in all parameters above（P〈0.05）.Conclusion： Shenfu injection has a certain protective effect on the severe head injury.