摘要
目的探讨镇痛药对女性colles骨折愈合的影响,为临床用药提供依据。方法选取60例colles骨折女性患者,随机分为盐酸曲马多组(n=20,服用盐酸曲马多一日100 mg)、双氯芬酸钠组(n=20,服用双氯酚酸钠一日75 mg)和对照组(n=20,不接受镇痛药物治疗),治疗均为期3周。以目测类比评分(VAS)和影像学观察结果评估病例骨折愈合情况。结果复位后前3周盐酸曲马多组与双氯芬酸钠组病例VAS均低于对照组,且差异有显著统计学意义(P<0.01)。影像学平均灰度比值评价结果,盐酸曲马多组略高于对照组,差异无统计学意义(P>0.05);双氯芬酸钠组低于对照组,且差异有显著统计学意义(P<0.01)。结论双氯酚酸钠可能延缓女性colles骨折愈合时间,盐酸曲马多对骨折愈合无明显不利影响。研究初步提示,骨折后或骨折术后需选用镇痛治疗者,宜首选弱阿片类中枢性镇痛药。
Objective To investigate the effect of analgesics on women colles fracture. Methods Sixty women with colles fracture were randomly divided into tramadol hydrochloride group （n=20, tramadol hydrochloride 100 mg per day）, diclofenac sodium group （n=20, diclofenac sodium 75 mg per day ） and control group （n=20）. The course of treatment was 3 weeks. The visual analogue scale （VAS） and the change of bone quantity were evaluated respectively. Results VAS of tramadol hydrochloride group as well as that of diclofenac sodium group was lower than that of control group at the first 3 weeks （P〈0.01）. The quantity of bone in diclofenac sodium group was lower than that in control group （P〈0.01）. Conclusion The application of diclofcnac sodium may delay the women colles fracture healing and tremadol hydrochloride may have less adverse effect on fracture healing. Central analgesics may be the first choice for pain-killer after fracture in clinic.
出处
《世界临床药物》
CAS
2010年第5期287-290,共4页
World Clinical Drug
