期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

硫化氢对脑缺血再灌注损伤大鼠血清及脑组织NO和NOS的影响 被引量：9

Effects of H_2S on NO and NOS of serum and brain tissue in cerebral ischemia-reperfusion injury rats
下载PDF
导出
摘要 目的探讨硫化氢(H2S)对脑缺血再灌注损伤大鼠血清及脑组织NO和NOS的影响。方法将大鼠随机分为对照组、模型组和模型+NaHS组,采用大脑中动脉阻断法制备大鼠脑缺血再灌注模型,再灌注前30 min给予模型+NaSH组大鼠腹腔注射NaHS,分光光度法检测脑缺血再灌注损伤大鼠血清及脑组织NO和NOS的浓度变化。结果模型+NaHS组大鼠NO、NOS含量较模型组大鼠显著下降(P均<0.05),而与对照组接近(P均>0.05)。结论H2S在脑缺血再灌注损伤中可能起着重要作用。 Objective It is to explore the effect of hydrogen sulfide（H2S） in cerebral ischemia-reperfusion injury in rats.Methods The rats were randomly divided into control group,model group and model＋NaHS group.Ischemia-reperfusion models of rats were established by middle cerebral artery occlusion mothod.The rats in model＋NaSH group were given NaHS by intraperitoneal injection at 30 min before reperfusion.The concentrations of NO and NOS in the rats with cerebral ischemia-reperfusion were determined by absorption spectrometry.Results The contents of NO and NOS in model＋NaHS group were significantly lower than that in model group（P0.05）,while they were similar to the control group（P0.05）.Conclusion H2S may play an important role in cerebral ischemia-reperfusion injury.
作者 熊文欣 李文峰
机构地区 贵州省修文县中医院
出处 《现代中西医结合杂志》 CAS 2010年第16期1971-1972,共2页 Modern Journal of Integrated Traditional Chinese and Western Medicine
关键词 H2S 脑缺血 再灌注损伤 NO NOS H2S cerebral ischemia reperfusion injury NO NOS
分类号 R-332 [医药卫生]
  • 相关文献

参考文献9

  • 1Malinski T,Bailey F,Zhang ZG,et al.Nitric oxide measured by aprophric microsensor in rat brain after transient middle cerebral artery occlussion[J].J Cereb Blood Flow Metab,1993,13:355-358.
  • 2Tominage T,Sato S,Ohnishi T,et al.Potentiation of nitric oxide formation following bilateral carotid occlusion and focal cerebral ischemia in the rat in vivo detection of the nitric oxide radical by electron paramagnetic resonance spin rapping[J].Brain Rev,1993,614:342-346.
  • 3Asano T.Oxyhenog lobin as the principil cause of cerebral vasospasm:a holistil view of its actions[J].Crit Rev Neurosblly,1999,9(2):218.
  • 4Zhong GZ,Chen FR,Cheng YQ,et al.The role of hydrogen sulfide in the pathogenesis of hypertension in rats induced by inhibition of notric oxide synthase[J].J Hypertension,2003,21(10):1879-1885.
  • 5耿彬,杜军保,唐朝枢.内源性H_2S——一种新的气体信号分子[J].生理科学进展,2002,33(3):255-258. 被引量：65
  • 6Bederson JB,Pitts LH,Tsuji M,et al.Rat middle cerebral artery occlusion:evaluation of the model and development of a neurologic examination[J].Stroke,1986,17(3):472-476.
  • 7Zhao W,Zhang J,Lu Y,et al.The vasorelaxant effect of H2S as a novel endogenous gaseous K (ATP) chanel opener[J].EMBO J,2001,20:6008-6016.
  • 8Zhang CY,Du JB,Bu DF,et al.The regularory effect of hydrogen sulfide on hypoxic pulmonary hypertension in rats[J].Biochem Biophys Res Commun,2003,302(4):810-816.
  • 9Osei SY,Ahima RS,Fabry ME,et al.Immunohisto chemical localization of hepatic nitric oxide synthase in normal and transgenic sickle cell mice:the effect of hypoxia[J].Bolld,1996,88(9):3585-3588.

二级参考文献10

  • 1Searcy D G,Lee S H.Sulfur reduction by human erythrocytes[].Journal of Experimental Zoology.1998
  • 2Abe K,Kimura H.The possible role of hydrogen sulfide as an endogenous neuromodulator[].The Journal of Neuroscience.1996
  • 3Kimura H.Hydrogen sulfide induces cyclic AMP and modulates the NMDA receptor[].Biochemical and Biophysical Research Communications.2000
  • 4Bhambhani Y,Burnham R,Snydmiller G,et al.Effects of 10-ppm hydrogen sulfide inhalation in exercising men and women.Cardiovascular, metabolic, and biochemical responses[].Journal of Occupational and Environmental Medicine.1997
  • 5Furne J,Springfield J,Koenig T,et al.Oxidation of hydrogen sulfide and methanethiol to thiosulfate by rat tissues:a specialized function of the colonic mucosa[].Biochemical Pharmacology.2001
  • 6Furne J,Springfield J,Koenig T,et al.Oxidation of hydrogen sulfide and methanethiol to thiosulfate by rat tissues:a specialized function of the colonic mucosa[].Biochemical Pharmacology.2001
  • 7Khan A A,Schuler M M,Prior M G,et al.Effects of hydrogen sulfide exposure on lung mitochondrial respiratory chain enzymes in rats[].Toxicology and Applied Pharmacology.1990
  • 8Zhao W,Zhang J,Lu Y,et al.The vasorelaxant effect of H(2) S as a novel endogenous gaseous K (ATP) channel opener[].EMBO Journal.2001
  • 9Hosoki R,Matsuki N,Kimura H.The possible role of hydrogen sulfide as an endogenous smooth muscle relaxant in synergy with nitric oxide[].Biochemical and Biophysical Research Communications.1997
  • 10Partlo LA,Sainsbury RS,Roth SH.Effects of repeated hydrogen sulphide (H2 S) exposure on learning and memory in the adult rat[].Neurotoxicology.2001

共引文献64

同被引文献81

引证文献9

二级引证文献43

现代中西医结合杂志
2010年 第16期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部