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伊马替尼治疗慢性粒细胞白血病耐药的机制及新进展 被引量:5

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摘要 目前,伊马替尼(imatinib mesylate,Gleevec/Glivec)是治疗慢粒的一线药物,属于ABL酪氨酸激酶抑制剂,是以ABL蛋白激酶的ATP结合位点为基础而设计合成。它通过抑制BCR-ABL自身磷酸化和底物磷酸化,而抑制细胞增殖和诱导凋亡。
作者 肖芸 王小中
出处 《江西医药》 CAS 2010年第4期361-364,共4页 Jiangxi Medical Journal
基金 国家自然科学基金项目(NO30700328)
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参考文献25

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