犀角地黄汤合消风散对慢性皮炎湿疹模型小鼠血清LTB4、LTC4水平的影响

Study on the Impact of Serum LTB,LTC4 Levels of Chronic Dermatitis and Eczema Mice Model Treated by XiJiaoDiHuang Decoction and XiaoFeng Powder

目的:观察犀角地黄汤合消风散对慢性皮炎湿疹模型小鼠血清LTB4、LTC4水平的影响。方法:50只小鼠随机分为5组,致敏小鼠,实验组采用犀角地黄汤合消风散煎剂给药17天,末次激发后24h处死小鼠,使用酶联免疫吸附试验对小鼠血清LTB4、LTC4进行检测。结果:犀角地黄汤合消风散中药干预1、2组LTB4检测结果分别为0.282ng/ml、0.313ng/ml,与模型组相比有非常显著和明显的差异(P<0.001和P<0.05),LTC4检测结果中药干预组分别为1.509ng/ml、1.602ng/ml,与模型组比较显著的差异(P<0.01)。结论:犀角地黄汤合消风散对慢性皮炎湿疹模型小鼠血清LTB4、LTC4水平有显著的调节作用。

Objective：Inspection the impact of mouse Serum LTB4/LTC4 levels on XijiaoDiHuang Decoction and XiaoFeng Powder of mouse chronic dermatits and eczema model.Methods：50 mice were randomly divided into five groups,Sensitized mice,experimental group were treated with XiJiaoDiHuang Decoction and XiaoFeng powder administration for 17 days,the last challenge after the mice were sacrificed 24h,using enzyme-linked immunosorbent assay for serum LTB4,LTC4 for testing.Results：DiHuang Decoction and XiaoFeng powder＇s 1,2 intervention group LTB4 test results were 0.282 ng/ml,0.313ng/ml,compared with the model group,a very significant and obvious difference（P〈0.001 and P〈0.05）,LTC4 test results of Chinese medicine in the intervention group were 1.509ng/ml.1.602ng/ml,with the model group were significantly different（P〈0.01）.Conclusions：XiJiaoDiHuang Decoction and XiaoFeng Powder has a significant regulatory role on mouse model of chronic dermatitis and eczema Serum LTB4,LTC4 levels.