摘要
目的:观察犀角地黄汤合消风散对慢性皮炎湿疹模型小鼠血清LTB4、LTC4水平的影响。方法:50只小鼠随机分为5组,致敏小鼠,实验组采用犀角地黄汤合消风散煎剂给药17天,末次激发后24h处死小鼠,使用酶联免疫吸附试验对小鼠血清LTB4、LTC4进行检测。结果:犀角地黄汤合消风散中药干预1、2组LTB4检测结果分别为0.282ng/ml、0.313ng/ml,与模型组相比有非常显著和明显的差异(P<0.001和P<0.05),LTC4检测结果中药干预组分别为1.509ng/ml、1.602ng/ml,与模型组比较显著的差异(P<0.01)。结论:犀角地黄汤合消风散对慢性皮炎湿疹模型小鼠血清LTB4、LTC4水平有显著的调节作用。
Objective:Inspection the impact of mouse Serum LTB4/LTC4 levels on XijiaoDiHuang Decoction and XiaoFeng Powder of mouse chronic dermatits and eczema model.Methods:50 mice were randomly divided into five groups,Sensitized mice,experimental group were treated with XiJiaoDiHuang Decoction and XiaoFeng powder administration for 17 days,the last challenge after the mice were sacrificed 24h,using enzyme-linked immunosorbent assay for serum LTB4,LTC4 for testing.Results:DiHuang Decoction and XiaoFeng powder's 1,2 intervention group LTB4 test results were 0.282 ng/ml,0.313ng/ml,compared with the model group,a very significant and obvious difference(P〈0.001 and P〈0.05),LTC4 test results of Chinese medicine in the intervention group were 1.509ng/ml.1.602ng/ml,with the model group were significantly different(P〈0.01).Conclusions:XiJiaoDiHuang Decoction and XiaoFeng Powder has a significant regulatory role on mouse model of chronic dermatitis and eczema Serum LTB4,LTC4 levels.
出处
《四川中医》
2010年第5期16-18,共3页
Journal of Sichuan of Traditional Chinese Medicine