王不留行防治去势大鼠骨质疏松症的实验研究

Experimental Study of Preventing Ovariectomized Rats from Osteoporosis by Vaccaria segetalis

目的:探讨王不留行防治去势大鼠骨质疏松症的作用。方法:运用切除大鼠卵巢的方法建立大鼠去势骨质疏松模型,分假手术组、模型组(去除卵巢组)、E2组(去除卵巢+尼尔雌醇)、药物组(去除卵巢+王不留行)。术后3个月,测血清IL-1、IL-6、TNF-α含量。结果:王不留行可明显降低血清IL-1、IL-6、TNF-α含量(P<0.01)。结论:王不留行对去势大鼠骨质疏松症有明显的防治作用,这种作用可能与王不留行的雌激素活性,降低骨的转移率和增加骨形成有关。

Objective：To study the effect of Vaccaria segetalis on the prevention of osteoporosis in ovariectomized rats.Methods：Osteoporosis model was established by means of ovariectomy.which were divided into sham operation group,ovariectomized group,ovariectomized-nilestriol group and ovariectomized-Vaccaria segetalis group.The test of IL-1、IL-6、TNF-α in the serum were measured.Results：Vaccaria segetalis can decrease the concentration of IL-1、IL-6、TNF-α（P〈0.01）.Conclusions：Vaccaria segetalis has antiosteoporotic effects on ovariectomized rats by inhibiting the bone turnover and improves bone forming by active of female hormone.