正常足月分娩产妇羊水中组织因子测定的临床意义

Tissue Factor of Amniotic Fluid with Normal Full-Term Delivery of Maternal in Clinical

目的:探讨正常足月分娩产妇羊水中组织因子(tissuefactor,TF)测定的临床意义。方法:用ELISA方法分别测定116例正常足月妊娠产妇血浆、羊水、羊水上清液及羊水沉渣中TF抗原水平,并将结果作对比分析。结果:正常足月妊娠血浆、羊水、羊水上清液、羊水沉渣中TF抗原水平分别为32.1±7.1ng/L、412.3±169.2ng/L、352.4±162.1ng/L、1 356.8±594.6ng/L。三种不同成分的羊水TF抗原水平与血浆比较,均有显著性差异(P<0.01);羊水沉渣中TF抗原水平与未离心羊水、羊水上清液比较,亦有显著性差异(P<0.01)。结论:正常足月妊娠羊水中有大量的TF,羊水有形成分中TF抗原水平最高,羊水中的TF可能是羊水栓塞引发DIC的启动因子,可以通过检测母血及羊水中的组织因子来辅助诊断羊水栓塞。

Objective： Discussions on tissue factor of amniotic for normal full- term delivery of maternal in clinical. Method： Plasma, amniotic and its clear liquid and precipitation were determined using ELISA method to 116 examples of normal full- term delivery of maternal. Results： It was found that the corresponding results of tissue factor with 32.1 ± 7.1 ng/L,412.3 ±169.2ng/L,352.4±162. lng/L and 1 356.8 ± 594.6ng/L could be obtained separately.Significant difference of tissue factor could be afforded between precipitation with untreated amniotic, and its clear liquid. Conclusion： Large number of tissue factor could be found in amniotic of normal full - term pregnancy, and the highest results founded in phys- ical composition. These results might be attributed to the start factors of DIC were triggered by amniotic fluid embolism. So, the amniotic fluid embolism were be detected by Matemal and tissue factor of amniotic fluid.